On the statistical significance of nucleic acid similarities

The statistical distribution of nucleic acid similarities.

All pairs of a large set of known vertebrate DNA sequences were searched by computer for most similar segments. Analysis of this data shows that the computed similarity scores are distributed proportionally to the logarithm of the product of the lengths of the sequences involved. This distribution is closely related to recent results of Erdos and others on the longest run of heads in coin tossi...

Retrieval accuracy, statistical significance and compositional similarity in protein sequence database searches

Protein sequence database search programs may be evaluated both for their retrieval accuracy--the ability to separate meaningful from chance similarities--and for the accuracy of their statistical assessments of reported alignments. However, methods for improving statistical accuracy can degrade retrieval accuracy by discarding compositional evidence of sequence relatedness. This evidence may b...

Statistical and Practical Significance of Articles at Sports Biomechanics Conferences

Background. The importance of using statistical approaches has increased and became necessary for researchers and specialists in sports biomechanics because they need more objective and accurate methods to increase knowledge. Objectives. Evaluate the reality of using practical significance in the articles published in scientific conferences in the biomechanical sport. Methods. One hundred twe...

The nucleic acid of African Horse-Sickness Virus

Cellular Morphology and Immunologic Properties of Escherichia coli Treated With Antimicrobial Antisense Peptide Nucleic Acid

  Background & Objectives: Antisense peptide nucleic acids (PNA) that target growth essential genes show potent bactericidal properties without cell lysis. We considered the possibility that whether PNA treatment influence the bacteria total nucleic acids content and apply approach to develop a new delivery system to Dendritic cells (DCs). DCs are the most potent antigen presenting cells in th...